๊ด€์ ˆ์—ผ3๋‹จ๊ณ„ 1
๊ณจ๊ด€์ ˆ์—ผ, ์–ด๋–ป๊ฒŒ ์ง„ํ–‰๋˜๋Š” ๊ฑธ๊นŒ? ๋‚˜๋Š” ๊ด€์ ˆ์—ผ์ผ๊นŒ?

1. ์—ฐ๊ณจ ํŒŒ๊ดด (Cartilage destruction)์ •์ƒ ์—ฐ๊ณจ์€ ๊ด€์ ˆ์˜ ์›€์ง์ž„์„ ๋ถ€๋“œ๋Ÿฝ๊ฒŒ ํ•˜๊ณ  ์ถฉ๊ฒฉ์„ ํก์ˆ˜ํ•˜๋Š” ์—ญํ• ์„ ํ•ฉ๋‹ˆ๋‹ค.์ฃผ๋กœ Type II collagen๊ณผ proteoglycan(ํŠนํžˆ aggrecan)์œผ๋กœ ๊ตฌ์„ฑ๋˜์–ด ํƒ„์„ฑ๊ณผ ๊ฒฌ๊ณ ์„ฑ์„ ๊ฐ€์ง‘๋‹ˆ๋‹ค. ๊ณจ๊ด€์ ˆ์—ผ์—์„œ๋Š”**์—ฐ๊ณจ ์„ธํฌ(์—ฐ๊ณจ์„ธํฌ, chondrocyte)**์˜ ๊ธฐ๋Šฅ ๋ถ€์ „ → ์„ธํฌ๊ฐ€ ์†์ƒ๋˜๊ณ  apoptosis(์„ธํฌ์‚ฌ๋ฉธ)์ด ์ง„ํ–‰๋ฉ๋‹ˆ๋‹ค.๊ธฐ์งˆ(matrix) ๋ถ„ํ•ด ํšจ์†Œ(์˜ˆ: MMPs: Matrix Metalloproteinases, ADAMTS: a disintegrin and metalloproteinase with thrombospondin motifs)๊ฐ€ ๊ณผํ™œ์„ฑํ™”๋˜์–ด, ์ฝœ๋ผ๊ฒ๊ณผ ํ”„๋กœํ…Œ์˜ค๊ธ€๋ฆฌ์นธ์„ ๋ถ„ํ•ดํ•ฉ๋‹ˆ๋‹ค.์—ฐ๊ณจ ํ‘œ๋ฉด์ด ๊ฑฐ์น ์–ด์ง€๊ณ  → **๊ท ์—ด(fibri..
๋‘๋“œ๋ฆฌ๋ฉฐ๋ฐฐ์šฐ๋Š” 2025.04.28
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